Archives of Clinical Infectious Diseases

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Zika Virus Infection during Pregnancy; Maternofetal Risk Assessment, Transmission, Complications, and Management: A Review of the Literature

Muhammad Rehan Sarwar 1 , * , Anum Saqib 1 and Sadia Iftikhar 2
Authors Information
1 Department of Pharmacy, The Islamia University of Bahawalpur, Punjab, Pakistan
2 Akhtar Saeed College of Pharmaceutical Sciences, Lahore, Pakistan
Article information
  • Archives of Clinical Infectious Diseases: June 2018, 13 (3); e12848
  • Published Online: June 24, 2018
  • Article Type: Review Article
  • Received: May 8, 2017
  • Accepted: September 19, 2017
  • DOI: 10.5812/archcid.12848

To Cite: Rehan Sarwar M, Saqib A, Iftikhar S. Zika Virus Infection during Pregnancy; Maternofetal Risk Assessment, Transmission, Complications, and Management: A Review of the Literature, Arch Clin Infect Dis. 2018 ; 13(3):e12848. doi: 10.5812/archcid.12848.

Abstract
Copyright © 2018, Archives of Clinical Infectious Diseases. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Context
2. Evidence Acquisition
3. Results and Discussions
4. Conclusions
References
  • 1. Stagg D, Hurst HM. Zika Virus and Pregnancy. Nurs Womens Health. 2016;20(3):299-304. doi: 10.1016/j.nwh.2016.03.001. [PubMed: 27287356].
  • 2. van Well GTJ, Daalderop LA, Wolfs T, Kramer BW. Human perinatal immunity in physiological conditions and during infection. Mol Cell Pediatr. 2017;4(1):4. doi: 10.1186/s40348-017-0070-1. [PubMed: 28432664]. [PubMed Central: PMC5400776].
  • 3. Racicot K, Mor G. Risks associated with viral infections during pregnancy. J Clin Invest. 2017;127(5):1591-9. doi: 10.1172/JCI87490. [PubMed: 28459427]. [PubMed Central: PMC5409792].
  • 4. Lucey D, Cummins H, Sholts S. Congenital Zika Syndrome in 2017. JAMA. 2017;317(13):1368-9. doi: 10.1001/jama.2017.1553. [PubMed: 28384812].
  • 5. Ruddiman WF, Ellis EC, Kaplan JO, Fuller DQ. Geology. Defining the epoch we live in. Science. 2015;348(6230):38-9. doi: 10.1126/science.aaa7297. [PubMed: 25838365].
  • 6. Petersen LR, Jamieson DJ, Powers AM, Honein MA. Zika Virus. N Engl J Med. 2016;374(16):1552-63. doi: 10.1056/NEJMra1602113. [PubMed: 27028561].
  • 7. Igbinosa ,I, Rabe IB, Oduyebo T, Rasmussen SA. Zika Virus: Common Questions and Answers. Am Fam Physician. 2017;95(8):507-13. [PubMed: 28409618].
  • 8. Roundy CM, Azar SR, Rossi SL, Huang JH, Leal G, Yun R, et al. Variation in Aedes aegypti Mosquito Competence for Zika Virus Transmission. Emerg Infect Dis. 2017;23(4):625-32. doi: 10.3201/eid2304.161484. [PubMed: 28287375]. [PubMed Central: PMC5367433].
  • 9. Hayes EB. Zika virus outside Africa. Emerg Infect Dis. 2009;15(9):1347-50. doi: 10.3201/eid1509.090442. [PubMed: 19788800]. [PubMed Central: PMC2819875].
  • 10. Musso D, Gubler DJ. Zika Virus. Clin Microbiol Rev. 2016;29(3):487-524. doi: 10.1128/CMR.00072-15. [PubMed: 27029595]. [PubMed Central: PMC4861986].
  • 11. European Center for Disease Prevention and Control. Rapid risk assessment and Zika virus disease epidemic. 2017. Available from: https://ecdc.europa.eu/en/publications-data/rapid-risk-assessment-zika-virus-disease-epidemic-10th-update-4-april-2017.
  • 12. Boeuf P, Drummer HE, Richards JS, Scoullar MJ, Beeson JG. The global threat of Zika virus to pregnancy: epidemiology, clinical perspectives, mechanisms, and impact. BMC Med. 2016;14(1):112. doi: 10.1186/s12916-016-0660-0. [PubMed: 27487767]. [PubMed Central: PMC4973112].
  • 13. Samarasekera U, Triunfol M. Concern over Zika virus grips the world. Lancet. 2016;387(10018):521-4. doi: 10.1016/S0140-6736(16)00257-9. [PubMed: 26852261].
  • 14. Messina JP, Kraemer MU, Brady OJ, Pigott DM, Shearer FM, Weiss DJ, et al. Mapping global environmental suitability for Zika virus. Elife. 2016;5. doi: 10.7554/eLife.15272. [PubMed: 27090089]. [PubMed Central: PMC4889326].
  • 15. Countries A. Territories with Active Zika Virus Transmission. 2016. Available from: https://www.cdc.gov/zika/geo/active-countries.html.
  • 16. Honein MA, Dawson AL, Petersen EE, Jones AM, Lee EH, Yazdy MM, et al. Birth Defects Among Fetuses and Infants of US Women With Evidence of Possible Zika Virus Infection During Pregnancy. JAMA. 2017;317(1):59-68. doi: 10.1001/jama.2016.19006. [PubMed: 27960197].
  • 17. World Health Organization. Zika virus country classification scheme: interim guidance. WHO. 2017.
  • 18. Rasmussen SA, Jamieson DJ, Honein MA, Petersen LR. Zika Virus and Birth Defects--Reviewing the Evidence for Causality. N Engl J Med. 2016;374(20):1981-7. doi: 10.1056/NEJMsr1604338. [PubMed: 27074377].
  • 19. Cauchemez S, Besnard M, Bompard P, Dub T, Guillemette-Artur P, Eyrolle-Guignot D, et al. Association between Zika virus and microcephaly in French Polynesia, 2013–15: a retrospective study. The Lancet. 2016;387(10033):2125-32. doi: 10.1016/s0140-6736(16)00651-6.
  • 20. Kleber de Oliveira W, Cortez-Escalante J, De Oliveira WT, do Carmo GM, Henriques CM, Coelho GE, et al. Increase in Reported Prevalence of Microcephaly in Infants Born to Women Living in Areas with Confirmed Zika Virus Transmission During the First Trimester of Pregnancy - Brazil, 2015. MMWR Morb Mortal Wkly Rep. 2016;65(9):242-7. doi: 10.15585/mmwr.mm6509e2. [PubMed: 26963593].
  • 21. Driggers RW, Ho CY, Korhonen EM, Kuivanen S, Jaaskelainen AJ, Smura T, et al. Zika Virus Infection with Prolonged Maternal Viremia and Fetal Brain Abnormalities. N Engl J Med. 2016;374(22):2142-51. doi: 10.1056/NEJMoa1601824. [PubMed: 27028667].
  • 22. Chitti SV, Prasad AK, Saxena SK. Emerging Zika virus disease: a public health emergency of global concern. Virusdisease. 2016;27(3):211-4. doi: 10.1007/s13337-016-0317-9. [PubMed: 28466030]. [PubMed Central: PMC5394706].
  • 23. de Araújo JSS, Regis CT, Gomes RGS, Tavares TR, dos Santos CR, Assunção PM, et al. Microcephaly in north-east Brazil: a retrospective study on neonates born between 2012 and 2015. B World Health Organ. 2016;94(11):835.
  • 24. Duffy MR, Chen TH, Hancock WT, Powers AM, Kool JL, Lanciotti RS, et al. Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med. 2009;360(24):2536-43. doi: 10.1056/NEJMoa0805715. [PubMed: 19516034].
  • 25. Relich RF, Loeffelholz M. Zika Virus. Clin Lab Med. 2017;37(2):253-67. doi: 10.1016/j.cll.2017.01.002. [PubMed: 28457349].
  • 26. Citil Dogan A, Wayne S, Bauer S, Ogunyemi D, Kulkharni SK, Maulik D, et al. The Zika virus and pregnancy: evidence, management, and prevention. The Journal of Maternal-Fetal & Neonatal Medicine. 2017;30(4):386-96.
  • 27. Besnard M, Lastere S, Teissier A, Cao-Lormeau V, Musso D. Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014. Euro Surveill. 2014;19(13). [PubMed: 24721538].
  • 28. Yuan S, Luo Q, Zhang ZW, Li ZL. Commentary: Teratogenic effects of the Zika virus and the role of the placenta. Front Cell Infect Microbiol. 2017;7:62. doi: 10.3389/fcimb.2017.00062. [PubMed: 28316955]. [PubMed Central: PMC5334333].
  • 29. Adibi JJ, Marques ETJ, Cartus A, Beigi RH. Teratogenic effects of the Zika virus and the role of the placenta. Lancet. 2016;387(10027):1587-90. doi: 10.1016/S0140-6736(16)00650-4. [PubMed: 26952548].
  • 30. Quicke KM, Bowen JR, Johnson EL, McDonald CE, Ma H, O’Neal JT, et al. Zika Virus Infects Human Placental Macrophages. Cell Host Microbe. 2016;20(1):83-90. doi: 10.1016/j.chom.2016.05.015.
  • 31. D'Ortenzio E, Matheron S, Yazdanpanah Y, de Lamballerie X, Hubert B, Piorkowski G, et al. Evidence of Sexual Transmission of Zika Virus. N Engl J Med. 2016;374(22):2195-8. doi: 10.1056/NEJMc1604449. [PubMed: 27074370].
  • 32. Hamel R, Dejarnac O, Wichit S, Ekchariyawat P, Neyret A, Luplertlop N, et al. Biology of Zika Virus Infection in Human Skin Cells. J Virol. 2015;89(17):8880-96. doi: 10.1128/JVI.00354-15. [PubMed: 26085147]. [PubMed Central: PMC4524089].
  • 33. Atif M, Azeem M, Sarwar MR, Bashir A. Zika virus disease: a current review of the literature. Infection. 2016;44(6):695-705. doi: 10.1007/s15010-016-0935-6.
  • 34. Nowakowski TJ, Pollen AA, Di Lullo E, Sandoval-Espinosa C, Bershteyn M, Kriegstein AR. Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells. Cell Stem Cell. 2016;18(5):591-6. doi: 10.1016/j.stem.2016.03.012. [PubMed: 27038591]. [PubMed Central: PMC4860115].
  • 35. Bayer A, Lennemann NJ, Ouyang Y, Bramley JC, Morosky S, Marques EJ, et al. Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection. Cell Host Microbe. 2016;19(5):705-12. doi: 10.1016/j.chom.2016.03.008. [PubMed: 27066743]. [PubMed Central: PMC4866896].
  • 36. Weisblum Y, Oiknine-Djian E, Vorontsov OM, Haimov-Kochman R, Zakay-Rones Z, Meir K, et al. Zika virus infects early-and mid-gestation human maternal-decidual tissues, inducing distinct innate tissue responses in the maternal-fetal interface. J virol. 2016:JVI. 01905-16.
  • 37. Delorme-Axford E, Bayer A, Sadovsky Y, Coyne CB. Autophagy as a mechanism of antiviral defense at the maternal-fetal interface. Autophagy. 2013;9(12):2173-4. doi: 10.4161/auto.26558. [PubMed: 24231730].
  • 38. Sarwar MR, Saqib A. Zika virus Infection during Pregnancy and its Management. J Mol Pathol Epidemiol. 2017;2. S1.
  • 39. Heymann DL, Hodgson A, Sall AA, Freedman DO, Staples JE, Althabe F, et al. Zika virus and microcephaly: why is this situation a PHEIC? Lancet. 2016;387(10020):719-21. doi: 10.1016/S0140-6736(16)00320-2. [PubMed: 26876373].
  • 40. Sousa AQ, Cavalcante DIM, Franco LM, Araujo FMC, Sousa ET, Valenca-Junior JT, et al. Postmortem Findings for 7 Neonates with Congenital Zika Virus Infection. Emerg Infect Dis. 2017;23(7):1164-7. doi: 10.3201/eid2307.162019. [PubMed: 28459414]. [PubMed Central: PMC5512501].
  • 41. Mlakar J, Korva M, Tul N, Popovic M, Poljsak-Prijatelj M, Mraz J, et al. Zika Virus Associated with Microcephaly. N Engl J Med. 2016;374(10):951-8. doi: 10.1056/NEJMoa1600651. [PubMed: 26862926].
  • 42. Cavalheiro S, Lopez A, Serra S, Da Cunha A, da Costa MD, Moron A, et al. Microcephaly and Zika virus: neonatal neuroradiological aspects. Childs Nerv Syst. 2016;32(6):1057-60. doi: 10.1007/s00381-016-3074-6. [PubMed: 27080092]. [PubMed Central: PMC4882355].
  • 43. de Fatima Vasco Aragao M, van der Linden V, Brainer-Lima AM, Coeli RR, Rocha MA, Sobral da Silva P, et al. Clinical features and neuroimaging (CT and MRI) findings in presumed Zika virus related congenital infection and microcephaly: retrospective case series study. BMJ. 2016;353. i1901. doi: 10.1136/bmj.i1901. [PubMed: 27075009]. [PubMed Central: PMC4830901].
  • 44. Gilboa SM, Mai CT, Shapiro-Mendoza CK, Cragan JD, Moore CA, Meaney-Delman DM, et al. Population-based pregnancy and birth defects surveillance in the era of Zika virus. Birth Defects Res. 2017;109(5):372-8. doi: 10.1002/bdr2.1007. [PubMed: 28398681].
  • 45. Faheem M, Naseer MI, Rasool M, Chaudhary AG, Kumosani TA, Ilyas AM, et al. Molecular genetics of human primary microcephaly: an overview. BMC Med Genomics. 2015;8 Suppl 1. S4. doi: 10.1186/1755-8794-8-S1-S4. [PubMed: 25951892]. [PubMed Central: PMC4315316].
  • 46. Feldman HS, Jones KL, Lindsay S, Slymen D, Klonoff-Cohen H, Kao K, et al. Prenatal alcohol exposure patterns and alcohol-related birth defects and growth deficiencies: a prospective study. Alcohol Clin Exp Res. 2012;36(4):670-6. doi: 10.1111/j.1530-0277.2011.01664.x. [PubMed: 22250768].
  • 47. Wu KY, Zuo GL, Li XF, Ye Q, Deng YQ, Huang XY, et al. Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice. Cell Res. 2016;26(6):645-54. doi: 10.1038/cr.2016.58. [PubMed: 27174054]. [PubMed Central: PMC4897185].
  • 48. Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, et al. Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell Stem Cell. 2016;18(5):587-90. doi: 10.1016/j.stem.2016.02.016. [PubMed: 26952870]. [PubMed Central: PMC5299540].
  • 49. Willison HJ, Jacobs BC, van Doorn PA. Guillain-Barré syndrome. Lancet. 2016;388(10045):717-27. doi: 10.1016/s0140-6736(16)00339-1.
  • 50. Carod-Artal FJ, Wichmann O, Farrar J, Gascón J. Neurological complications of dengue virus infection. Lancet Neurol. 2013;12(9):906-19. doi: 10.1016/s1474-4422(13)70150-9.
  • 51. Cao-Lormeau VM, Blake A, Mons S, Lastere S, Roche C, Vanhomwegen J, et al. Guillain-Barre Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study. Lancet. 2016;387(10027):1531-9. doi: 10.1016/S0140-6736(16)00562-6. [PubMed: 26948433]. [PubMed Central: PMC5444521].
  • 52. Dirlikov E, Major CG, Mayshack M, Medina N, Matos D, Ryff KR, et al. Guillain-Barre Syndrome During Ongoing Zika Virus Transmission - Puerto Rico, January 1-July 31, 2016. MMWR Morb Mortal Wkly Rep. 2016;65(34):910-4. doi: 10.15585/mmwr.mm6534e1. [PubMed: 27584942].
  • 53. Yepez JB, Murati FA, Pettito M, Penaranda CF, de Yepez J, Maestre G, et al. Ophthalmic Manifestations of Congenital Zika Syndrome in Colombia and Venezuela. JAMA Ophthalmol. 2017;135(5):440-5. doi: 10.1001/jamaophthalmol.2017.0561. [PubMed: 28418539]. [PubMed Central: PMC5470423].
  • 54. McCarthy M. Severe eye damage in infants with microcephaly is presumed to be due to Zika virus. BMJ. 2016;352. i855. doi: 10.1136/bmj.i855. [PubMed: 26864344].
  • 55. Ventura LO, Ventura CV, Lawrence L, van der Linden V, van der Linden A, Gois AL. Visual impairment in children with congenital Zika syndrome. J AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus. 2017.
  • 56. Ventura CV, Ventura LO, Bravo-Filho V, Martins TT, Berrocal AM, Gois AL, et al. Optical Coherence Tomography of Retinal Lesions in Infants With Congenital Zika Syndrome. JAMA Ophthalmol. 2016;134(12):1420-7. doi: 10.1001/jamaophthalmol.2016.4283. [PubMed: 27832267].
  • 57. Ventura CV, Maia M, Travassos SB, Martins TT, Patriota F, Nunes ME, et al. Risk Factors Associated With the Ophthalmoscopic Findings Identified in Infants With Presumed Zika Virus Congenital Infection. JAMA Ophthalmol. 2016;134(8):912-8. doi: 10.1001/jamaophthalmol.2016.1784. [PubMed: 27228275].
  • 58. Fiorentino DG, Montero FJ. The Zika Virus and Pregnancy. Curr Obstet Gynecol Rep. 2016;5(3):234-8. doi: 10.1007/s13669-016-0171-1.
  • 59. Kindhauser MK, Allen T, Frank V, Santhana RS, Dye C. Zika: the origin and spread of a mosquito-borne virus. Bull World Health Organ. 2016;94(9):675-686C. doi: 10.2471/BLT.16.171082. [PubMed: 27708473]. [PubMed Central: PMC5034643].
  • 60. Women's Health Care Physicians. Practice Advisory: Updated Interim Guidance for Care of Obstetric Patients And Women Of Reproductive Age During a Zika Virus Outbreak. Perinatologiya I Pediatriya. 2016;1(65):8-17.
  • 61. American Society for Reproductive Medicine. American society for reproductive medicine. Guidance for Providers Caring for Women and Men Of Reproductive Age with Possible Zika Virus Exposure (Modified from CDC, FDA and WHO Published Guidance). ASRM; 2017. Available from: https://www.asrm.org/globalassets/asrm/asrm-content/news-and-publications/practice-guidelines/for-non-members/guidance_for_providers_zika_virus_exposure.pdf.
  • 62. World Health Organization. Pregnancy menagement in the context of Zika virus infection: interim guidance update. WHO; 2016. Available from: http://apps.who.int/iris/bitstream/handle/10665/204520/WHO_ZIKV_MOC_16.2_eng.pdf;jsessionid=030A429B3755E3F656B47FEC7B53A8A4?sequence=1.
  • 63. Rather IA, Kumar S, Bajpai VK, Lim J, Park YH. Prevention and Control Strategies to Counter ZIKA Epidemic. Front Microbiol. 2017;8:305. doi: 10.3389/fmicb.2017.00305. [PubMed: 28293228]. [PubMed Central: PMC5328966].
  • 64. Xu M, Lee EM, Wen Z, Cheng Y, Huang WK, Qian X, et al. Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen. Nat Med. 2016;22(10):1101-7. doi: 10.1038/nm.4184. [PubMed: 27571349]. [PubMed Central: PMC5386783].
  • 65. Sapparapu G, Fernandez E, Kose N, Bin C, Fox JM, Bombardi RG, et al. Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice. Nature. 2016;540(7633):443-7. doi: 10.1038/nature20564. [PubMed: 27819683]. [PubMed Central: PMC5583716].
  • 66. Center for Disease Control and Prevention. Zika Virus. May 3, 2017. Available from: https://www.cdc.gov/zika/pregnancy/protect-yourself.html.

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