Archives of Clinical Infectious Diseases

Published by: Kowsar

Discovery of New Drugs Against Tuberculosis: History Guides

Amit Kumar Verma 1 , * and Om Prakash Kalra 2
Authors Information
1 Department of Medicine, Division of TB and Chest, University College of Medical Sciences, Delhi, India
2 Department of Medicine, University College of Medical Sciences, Delhi, India
Article information
  • Archives of Clinical Infectious Diseases: October 5, 2012, 7 (4); 109-12
  • Published Online: October 5, 2012
  • Article Type: Review Article
  • Received: July 28, 2012
  • Revised: August 5, 2012
  • Accepted: August 25, 2012
  • DOI: 10.5812/archcid.15088

To Cite: Verma A K, Kalra O P. Discovery of New Drugs Against Tuberculosis: History Guides, Arch Clin Infect Dis. 2012 ; 7(4):109-12. doi: 10.5812/archcid.15088.

Copyright © 2012, Infectious Diseases and Tropical Medicine Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. History of Isoniazid
3. Trifluoperazine
4. Research on Anti-Tubercular Activity of TFP
5. Conclusions
  • 1. Ma Z, Lienhardt C, McIlleron H, Nunn AJ, Wang X. Global tuberculosis drug development pipeline: the need and the reality. Lancet. 2010; 375(9731): 2100-9[DOI][PubMed]
  • 2. Lopez-Munoz F, Alamo C, Juckel G, Assion HJ. Half a century of antidepressant drugs: on the clinical introduction of monoamine oxidase inhibitors, tricyclics, and tetracyclics. Part I: monoamine oxidase inhibitors. J Clin Psychopharmacol. 2007; 27(6): 555-9[DOI][PubMed]
  • 3. Lopez-Munoz F, Alamo C. Monoaminergic neurotransmission: the history of the discovery of antidepressants from 1950s until today. Curr Pharm Des. 2009; 15(14): 1563-86[PubMed]
  • 4. Drug Bank. Trifluoperazine. 2005;
  • 5. Falah AMS, Bhatnagar R, Bhatnagar N, Singh Y, Sidhu GS, Murthy PS, et al. On the presence of calmodulin-like protein in mycobacteria. FEMS microbiol letters. 1988; 56(1): 89-93
  • 6. Reddy PH, Burra SS, Murthy PS. Correlation between calmodulin-like protein, phospholipids, and growth in glucose-grown Mycobacterium phlei. Can J Microbiol. 1992; 38(4): 339-42[PubMed]
  • 7. Burra SS, Reddy H, Suryanarayana Murthy P. Effect of some antitubercular drugs on the calmodulin content of Mycobacterium tuberculosis. Indian J Clin Bioch. 1995; 10(2): 126-8[DOI]
  • 8. Gadre DV, Talwar V, Gupta HC, Murthy PS. Effect of trifluoperazine, a potential drug for tuberculosis with psychotic disorders, on the growth of clinical isolates of drug resistant Mycobacterium tuberculosis. Int Clin Psychopharmacol. 1998; 13(3): 129-31[PubMed]
  • 9. Katoch VM, Saxena N, Shivannavar CT, Sharma VD, Katoch K, Sharma RK, et al. Effect of trifluoperazine on in vitro ATP synthesis by Mycobacterium leprae. FEMS Immunol Med Microbiol. 1998; 20(2): 99-102[PubMed]
  • 10. Rao SP, Ratnakar P, Murthy PS, Catanzaro A. Inhibitory and bactericidal activity of the calmodulin antagonist, trifluoperazine, against Mycobacterium avium in vitro and within human monocyte-derived macrophages. Indian J Clin Bioch. 1995; 10(2): 77-84[DOI]
  • 11. Ratnakar P, Murthy PS. Antitubercular activity of trifluoperazine, a calmodulin antagonist. FEMS Microbiol Lett. 1992; 76(1-2): 73-6[PubMed]
  • 12. Gupta RL, Jain S, Talwar V, Gupta HC, Murthy PS. Studies on a new antitubercular drug, trifluoperazine: Its effect in combination with conventional antitubercular drugs in tubercular lymphadenitis. Indian J Clin Bioch. 1998; 13(2): 92-7[DOI][PubMed]
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