Archives of Clinical Infectious Diseases

Published by: Kowsar

Crimean-Congo Hemorrhagic Fever: A Reemerging Disease

Maliheh Metanat 1 , Batool Sharifi Mood 1 , * and Salehi Masoud 1
Authors Information
1 Infectious Diseases and Tropical Medicine Research Center, Boo-Ali Hospital, Zahedan University of Medical Sciences, Zahedan, IR Iran
Article information
  • Archives of Clinical Infectious Diseases: January 30, 2014, 9 (1); e20568
  • Published Online: January 25, 2014
  • Article Type: Review Article
  • Received: August 4, 2013
  • Revised: October 3, 2013
  • Accepted: August 10, 2013
  • DOI: 10.5812/archcid.20568

To Cite: Metanat M, Sharifi Mood B, Masoud S. Crimean-Congo Hemorrhagic Fever: A Reemerging Disease, Arch Clin Infect Dis. 2014 ; 9(1):e20568. doi: 10.5812/archcid.20568.

Copyright © 2014, Infectious Diseases and Tropical Medicine Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Evidence Acquisition
3. Results
4. Conclusions
  • 1. Mardani M, Keshtkar-Jahromi M. Crimean-Congo hemorrhagic fever. Arch Iran Med. 2007; 10(2): 204-14[PubMed]
  • 2. Alavi-Naini R, Moghtaderi A, Koohpayeh HR, Sharifi-Mood B, Naderi M, Metanat M, et al. Crimean-Congo hemorrhagic fever in Southeast of Iran. J Infect. 2006; 52(5): 378-82[DOI][PubMed]
  • 3. Sharifi-Mood B, Mardani M, Keshtkar-Jahromi M, Rahnavardi M, Hatami H, Metanat M. Clinical and epidemiologic features of Crimean-Congo hemorrhagic fever among children and adolescents from southeastern Iran. Pediatr Infect Dis J. 2008; 27(6): 561-3[DOI][PubMed]
  • 4. Crimean-Congo Hemorrhagic Fever..
  • 5. Sharifi-Mood B, Metanat M, Ghorbani-Vaghei A, Fayyaz-Jahani F, Akrami E. The outcome of patients with Crimean-Congo hemorrhagic fever in Zahedan, southeast of Iran: a comparative study. Arch Iran Med. 2009; 12(2): 151-3[PubMed]
  • 6. Sharifi Mood B, Alavi-Naini R, Metanat M, Rakhshani F. Ribavirin: an effective drug for treatment of children with Crimean Congo hemorrhagic fever: a seven years experience. Pak J Biol Sci. 2006; 9(8): 1598-600
  • 7. Mardani M, Pourkaveh B. Crimean-Congo Hemorrhagic Fever. Iran J Clin Infect Dis. 2012; 7(1): 36-42
  • 8. Sheikh AS, Sheikh AA, Sheikh NS, Rafi US, Asif M, Afridi F, et al. Bi-annual surge of Crimean-Congo haemorrhagic fever (CCHF): a five-year experience. Int J Infect Dis. 2005; 9(1): 37-42[PubMed]
  • 9. Fisher-Hoch SP, Khan JA, Rehman S, Mirza S, Khurshid M, McCormick JB. Crimean Congo-haemorrhagic fever treated with oral ribavirin. Lancet. 1995; 346(8973): 472-5[PubMed]
  • 10. Ergonul O, Celikbas A, Dokuzoguz B, Eren S, Baykam N, Esener H. Characteristics of patients with Crimean-Congo hemorrhagic fever in a recent outbreak in Turkey and impact of oral ribavirin therapy. Clin Infect Dis. 2004; 39(2): 284-7[DOI][PubMed]
  • 11. Whitehouse CA. Crimean–Congo hemorrhagic fever. Antiviral Res. 2004; 64(3): 145-60[DOI]
  • 12. Mirazimi A. Crimean-Congo Hemorrhagic Fever: A Global Perspective.. 2007; : 258–260
  • 13. Sheikh AS, Sheikh AA, Sheikh NS, Tariq M. Ribavirin an effective treatment of Crimean-Congo Haemorrhagic Fever. Pak J Medl Sci. 2004; 20(3): 201-6
  • 14. Centers for Disease C. Viral hemorrhagic fever: initial management of suspected and confirmed cases. MMWR Morb Mortal Wkly Rep. 1983; 32 Suppl 2: 27S-38S[PubMed]
  • 15. Centers for Disease C. Management of patients with suspected viral hemorrhagic fever. MMWR Morb Mortal Wkly Rep. 1988; 37 Suppl 3: 1-16[PubMed]
  • 16. Metanat M, Sharifi Mood B, Salehi M, Alavi Naini R. Clinical outcomes in Crimean-Congo hemorrhagic fever: A five-years experience in the treatment of patients in oral Ribavirin. Int J Virol. 2006; 2(1): 21-4[DOI]
  • 17. Izadi S, Salehi M. Evaluation of the efficacy of ribavirin therapy on survival of Crimean-Congo hemorrhagic fever patients: a case-control study. Jpn J Infect Dis. 2009; 62(1): 11-5[PubMed]
  • 18. Ergonul O. Crimean-Congo haemorrhagic fever. Lancet Infect Dis. 2006; 6(4): 203-14[DOI]
  • 19. Dilber E, Cakir M, Erduran E, Koksal I, Bahat E, Mutlu M, et al. High-dose methylprednisolone in children with Crimean-Congo haemorrhagic fever. Trop Doct. 2010; 40(1): 27-30[DOI][PubMed]
  • 20. Sharifi-Mood B, Alavi-Naini R, Metanat M, Mohammadi M, Shakeri A, Amjadi A. Efficacy of high-dose methylprednisolone in patients with Crimean-Congo haemorrhagic fever and severe thrombocytopenia. Trop Doct. 2013; 43(2): 49-53[DOI][PubMed]
  • 21. Ozkurt Z, Kiki I, Erol S, Erdem F, Yilmaz N, Parlak M, et al. Crimean-Congo hemorrhagic fever in Eastern Turkey: clinical features, risk factors and efficacy of ribavirin therapy. J Infect. 2006; 52(3): 207-15[DOI][PubMed]
  • 22. Erduran E, Bahadir A, Palanci N, Gedik Y. The treatment of crimean-congo hemorrhagic fever with high-dose methylprednisolone, intravenous immunoglobulin, and fresh frozen plasma. J Pediatr Hematol Oncol. 2013; 35(1)-24[DOI][PubMed]
  • 23. Salehi H, Salehi M, Adibi N, Salehi M. Comparative study between Ribavirin and Ribavirin plus Intravenous Immunoglobulin against Crimean Congo hemorrhagic fever. J Res Med Sci. 2013; 18(6): 497-500[PubMed]
  • 24. Sancakdar E, Guven AS, Uysal EB, Kaya A, Deveci K, Karapinar H, et al. Evaluation of cytokines as Th1/Th2 markers in pathogenesis of children with Crimean-Congo hemorrhagic fever. Int J Clin Exp Med. 2014; 7(3): 751-7[PubMed]
  • 25. Aydin H, Guven FM, Yildiz G, Bakir M, Celik C, Korkmaz I. Role of matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases-1 in Crimean-Congo hemorrhagic fever disease. Eur Rev Med Pharmacol Sci. 2014; 18(6): 861-8[PubMed]
  • 26. Mardani M, Namazee N. Close contact precautions could prevent an outbreak of crimean-congo hemorrhagic Fever: a case series report from southern part of tehran. Int J Prev Med. 2013; 4(6): 715-9[PubMed]
  • 27. van de Wal BW, Joubert JR, van Eeden PJ, King JB. A nosocomial outbreak of Crimean-Congo haemorrhagic fever at Tygerberg Hospital. Part IV. Preventive and prophylactic measures. S Afr Med J. 1985; 68(10): 729-32[PubMed]
  • 28. Keshtkar-Jahromi M, Sajadi MM, Ansari H, Mardani M, Holakouie-Naieni K. Crimean-Congo hemorrhagic fever in Iran. Antiviral Res. 2013; 100(1): 20-8[DOI][PubMed]
  • 29. Mardani M, Rahnavardi M, Sharifi-Mood B. Current treatment of Crimean-Congo hemorrhagic fever in children. Expert Rev Anti Infect Ther. 2010; 8(8): 911-8[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments