Archives of Clinical Infectious Diseases

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Laboratory Detection of Carbapenemases in Gram-Negative Bacteria

Hossein Goudarzi 1 , Arezou Taherpour 2 , Fatemeh Fallah 1 , Bita Pourkaveh 3 , Soroor Erfanimanesh 4 and Ali Hashemi 1 , *
Authors Information
1 Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
2 Department of Microbiology, Kurdistan University of Medical Sciences, Sanandaj, IR Iran
3 Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
4 Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, IR Iran
Article information
  • Archives of Clinical Infectious Diseases: April 30, 2016, 11 (2); e32816
  • Published Online: March 22, 2016
  • Article Type: Review Article
  • Received: August 30, 2015
  • Revised: March 26, 2016
  • Accepted: March 28, 2016
  • DOI: 10.5812/archcid.32816

To Cite: Goudarzi H, Taherpour A, Fallah F, Pourkaveh B, Erfanimanesh S, et al. Laboratory Detection of Carbapenemases in Gram-Negative Bacteria, Arch Clin Infect Dis. 2016 ; 11(2):e32816. doi: 10.5812/archcid.32816.

Abstract
Copyright © 2016, Infectious Diseases and Tropical Medicine Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Imipenemase-Type Beta-Lactamases
3. Verona Integron-Encoded-Type Beta-Lactamases
4. New-Delhi Metallo-Beta-Lactamases
5. Carbapenem-Hydrolysing Oxacillinase-48-Type Carbapenemase
6. <i>Klebsiella pneumoniae</i> Carbapenemase
7. How Can Metallo-Beta-Lactamases and Carbapenemases Producing Bacteria be Identified?
Acknowledgements
References
  • 1. Salahuddin P, Khan AU. Studies on structure-based sequence alignment and phylogenies of beta-lactamases. Bioinformation. 2014; 10(5): 308-13[DOI][PubMed]
  • 2. Rodriguez-Noriega E, Leon-Garnica G, Petersen-Morfin S, Perez-Gomez HR, Gonzalez-Diaz E, Morfin-Otero R. [Evolution of bacterial resistance to antibiotics in Mexico, 1973-2013]. Biomedica. 2014; 34 Suppl 1: 181-90[DOI][PubMed]
  • 3. Long TE, Williams JT. Cephalosporins currently in early clinical trials for the treatment of bacterial infections. Expert Opin Investig Drugs. 2014; 23(10): 1375-87[DOI][PubMed]
  • 4. Gholami M, Hashemi A, Hakemi-Vala M, Goudarzi H, Hallajzadeh M. Efflux Pump Inhibitor Phenylalanine-Arginine Β-Naphthylamide Effect on the Minimum Inhibitory Concentration of Imipenem in Acinetobacter baumannii Strains Isolated From Hospitalized Patients in Shahid Motahari Burn Hospital, Tehran, Iran. Jundishapur J microbiol. 2015; 8(10)[DOI]
  • 5. Taherpour A, Hashemi A. Detection of OqxAB efflux pumps, OmpK35 and OmpK36 porins in extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae isolates from Iran. Hippokratia. 2013; 17(4): 355-8[PubMed]
  • 6. Goudarzi H, Aghamohammad S, Hashemi A, Nikmanesh B, Noori M. Distribution of bla TEM, bla SHV and bla CTX-M genes among Escherichia coli isolates causing urinary tract infection in children. Arch Clin Infect Dis. 2013; 8(3)
  • 7. Ghazi M, Isadyar M, Gachkar L, Mahmoudi S, Goudarzi H, Eslami G, et al. Serum levels of mannose-binding lectin and the risk of infection in pediatric oncology patients with chemotherapy. J Pediatr Hematol Oncol. 2012; 34(2): 128-30[DOI][PubMed]
  • 8. Reardon S. Antibiotic resistance sweeping developing world. Nature. 2014; 509(7499): 141-2[DOI][PubMed]
  • 9. May M. Drug development: Time for teamwork. Nature. 2014; 509(7498)-5[DOI][PubMed]
  • 10. Hashemi A, Fallah F, Taherpour A, Goudarzi H, Tarashi S, Erfanimanesh S, et al. Detection of Metallo-beta-Lactamases, Extended-spectrum Beta-lactamases (ESBLs), Outer Membrane Porins among Klebsiella Pneumoniae Strains Isolated from Hospitalized Patients in Tehran. ZUMS J. 2015; 23(98): 89-102
  • 11. Jafari M, Fallah F, Borhan RS, Navidinia M, Karimi A, Tabatabaei SR, et al. The first report of CMY, aac (6′)-Ib and 16S rRNA methylase genes among Pseudomonas aeruginosa isolates from Iran. Arch Pediatr Infect Dis. 2013; 1(3): 109-12[DOI]
  • 12. Fallah F, Taherpour A, Hakemi Vala M, Hashemi A. Global Spread of New Delhi mettallo-beta-lactamase-1 (NDM-1). Arch Clin Infect Dis. 2012; 6(4): 171-7
  • 13. Harris PN, Tambyah PA, Paterson DL. beta-lactam and beta-lactamase inhibitor combinations in the treatment of extended-spectrum beta-lactamase producing Enterobacteriaceae: time for a reappraisal in the era of few antibiotic options? Lancet Infect Dis. 2015; 15(4): 475-85[DOI][PubMed]
  • 14. Amraei S, Eslami G, Taherpour A, Goudarzi H, Hashemi A. Detection of FOXMOX, and ACT genes in ESBL-producing Klebsiella Pneumoniae strains. J Mazandaran Univ Med Sci. 2014; 24(118): 11-20
  • 15. Fallah F, Taherpour A, Borhan RS, Hashemi A, Habibi M, Sajadi Nia R. Evaluation of Zataria MultiFlora Boiss and Carum copticum antibacterial activity on IMP-type metallo-beta-lactamase-producing Pseudomonas aeruginosa. Ann Burns Fire Disasters. 2013; 26(4): 193-8[PubMed]
  • 16. Gholipourmalekabadi M, Bandehpour M, Mozafari M, Hashemi A, Ghanbarian H, Sameni M, et al. Decellularized human amniotic membrane: more is needed for an efficient dressing for protection of burns against antibiotic-resistant bacteria isolated from burn patients. Burns. 2015; 41(7): 1488-97[DOI][PubMed]
  • 17. Walsh TR, Onken A, Haldorsen B, Toleman MA, Sundsfjord A. Characterization of a carbapenemase-producing clinical isolate of Bacteroides fragilis in Scandinavia: genetic analysis of a unique insertion sequence. Scand J Infect Dis. 2005; 37(9): 676-9[DOI][PubMed]
  • 18. Cornaglia G, Giamarellou H, Rossolini GM. Metallo-beta-lactamases: a last frontier for beta-lactams? Lancet Infect Dis. 2011; 11(5): 381-93[DOI][PubMed]
  • 19. King AM, Reid-Yu SA, Wang W, King DT, De Pascale G, Strynadka NC, et al. Aspergillomarasmine A overcomes metallo-beta-lactamase antibiotic resistance. Nature. 2014; 510(7506): 503-6[DOI][PubMed]
  • 20. Berrazeg M, Diene S, Medjahed L, Parola P, Drissi M, Raoult D, et al. New Delhi Metallo-beta-lactamase around the world: an eReview using Google Maps. Euro Surveill. 2014; 19(20)[PubMed]
  • 21. Liu W, Zou D, Li Y, Wang X, He X, Wei X, et al. Sensitive and rapid detection of the new Delhi metallo-beta-lactamase gene by loop-mediated isothermal amplification. J Clin Microbiol. 2012; 50(5): 1580-5[DOI][PubMed]
  • 22. Tempe DK. New Delhi metallo-beta-lactamase 1. Lancet Infect Dis. 2010; 10(11): 750-1[DOI][PubMed]
  • 23. Djahmi N, Dunyach-Remy C, Pantel A, Dekhil M, Sotto A, Lavigne JP. Epidemiology of carbapenemase-producing Enterobacteriaceae and Acinetobacter baumannii in Mediterranean countries. Biomed Res Int. 2014; 2014: 305784[DOI][PubMed]
  • 24. Bedenic B, Plecko V, Sardelic S, Uzunovic S, Godic Torkar K. Carbapenemases in gram-negative bacteria: laboratory detection and clinical significance. Biomed Res Int. 2014; 2014: 841951[DOI][PubMed]
  • 25. Fallah F, Hakemi Vala M, Hashemi A, Shams S. Emergence of novel plasmid-mediated beta-lactamase in klebsiella pneumonia (review article). Qom Univ Med Sci J. 2013; 6(24): 104
  • 26. Nordmann P, Cuzon G, Naas T. The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect Dis. 2009; 9(4): 228-36[DOI][PubMed]
  • 27. Peymani A, Nahaei MR, Farajnia S, Hasani A, Mirsalehian A, Sohrabi N, et al. High prevalence of metallo-beta-lactamase-producing acinetobacter baumannii in a teaching hospital in Tabriz, Iran. Jpn J Infect Dis. 2011; 64(1): 69-71[PubMed]
  • 28. Yousefi S, Farajnia S, Nahaei MR, Akhi MT, Ghotaslou R, Soroush MH, et al. Detection of metallo-beta-lactamase-encoding genes among clinical isolates of Pseudomonas aeruginosa in northwest of Iran. Diagn Microbiol Infect Dis. 2010; 68(3): 322-5[DOI][PubMed]
  • 29. Bahar MA, Jamali S, Samadikuchaksaraei A. Imipenem-resistant Pseudomonas aeruginosa strains carry metallo-beta-lactamase gene bla(VIM) in a level I Iranian burn hospital. Burns. 2010; 36(6): 826-30[DOI][PubMed]
  • 30. Khosravi AD, Mihani F. Detection of metallo-beta-lactamase-producing Pseudomonas aeruginosa strains isolated from burn patients in Ahwaz, Iran. Diagn Microbiol Infect Dis. 2008; 60(1): 125-8[DOI][PubMed]
  • 31. Shahcheraghi F, Nobari S, Rahmati Ghezelgeh F, Nasiri S, Owlia P, Nikbin VS, et al. First report of New Delhi metallo-beta-lactamase-1-producing Klebsiella pneumoniae in Iran. Microb Drug Resist. 2013; 19(1): 30-6[DOI][PubMed]
  • 32. Kalantar E, Torabi V, Salimizand H, Soheili F, Beiranvand S, Soltan Dallal MM. First Survey of Metallo-beta-Lactamase Producers in Clinical Isolates of Pseudomonas aeruginosa From a Referral Burn Center in Kurdistan Province. Jundishapur J Nat Pharm Prod. 2012; 7(1): 23-6[PubMed]
  • 33. Doosti M, Ramazani A, Garshasbi M. Identification and characterization of metallo-beta-lactamases producing Pseudomonas aeruginosa clinical isolates in University Hospital from Zanjan Province, Iran. Iran Biomed J. 2013; 17(3): 129-33[PubMed]
  • 34. Fallah F, Noori M, Hashemi A, Goudarzi H, Karimi A, Erfanimanesh S, et al. Prevalence of bla NDM, bla PER, bla VEB, bla IMP, and bla VIM Genes among Acinetobacter baumannii Isolated from Two Hospitals of Tehran, Iran. Scientifica (Cairo). 2014; 2014: 245162[DOI][PubMed]
  • 35. Neyestanaki DK, Mirsalehian A, Rezagholizadeh F, Jabalameli F, Taherikalani M, Emaneini M. Determination of extended spectrum beta-lactamases, metallo-beta-lactamases and AmpC-beta-lactamases among carbapenem resistant Pseudomonas aeruginosa isolated from burn patients. Burns. 2014; 40(8): 1556-61[DOI][PubMed]
  • 36. Noori N, Vandyosefi J, Sabet F, Ashrafi S, Ghazvini K. Frequency of IMP-1 and VIM Genes among Metallo-beta-Lactamase Producing Acinetobacter spp. Isolated from Health Care Associated Infections inNortheast of Iran. J Med Bacteriol. 2015; 2(3-4): 11-6
  • 37. Rasheed JK, Kitchel B, Zhu W, Anderson KF, Clark NC, Ferraro MJ, et al. New Delhi metallo-beta-lactamase-producing Enterobacteriaceae, United States. Emerg Infect Dis. 2013; 19(6): 870-8[DOI][PubMed]
  • 38. Rahmati Roodsari M, Fallah F, Taherpour A, Hakemi Vala M, Hashemi A. Carbapenem-resistant bacteria and laboratory detection methods. Arch Pediatr Infect Dis. 2014; 2(1): 188-91
  • 39. Shakibaie MR, Shahcheraghi F, Hashemi A, Adeli NS. Detection of TEM, SHV and PER Type Extended-Spectrum ß-Lactamase Genes among Clinical Strains of Pseudomonas aeruginosa Isolated from Burnt Patients at Shafa-Hospital, Kerman, Iran. Iranian J basic med sci. 2008; 11(2): 104-11
  • 40. Hashemi A, Shams S, Kalantar D, Taherpour A, Barati M. Antibacterial effect of Methanolic extract of Camellia Sinensis L. on Pseudomonas aeruginosa strains producing β-lactamases. J Gorgan Univ Med Sci. 2012; 14(1): 136-42
  • 41. Hashemi A, Shams S, Barati M, Samedani A. Antibacterial effects of methanolic extracts of Zataria multiflora, Myrtus communis and Peganum harmala on Pseudomonas aeruginosa producing ESBL. Arak Med Univ J. 2011; 14(4): 104-12
  • 42. Nordmann P, Poirel L, Carrer A, Toleman MA, Walsh TR. How to detect NDM-1 producers. J Clin Microbiol. 2011; 49(2): 718-21[DOI][PubMed]
  • 43. Fallah F, Borhan RS, Hashemi A. Detection of bla(IMP) and bla(VIM) metallo-beta-lactamases genes among Pseudomonas aeruginosa strains. Int J Burns Trauma. 2013; 3(2): 122-4[PubMed]
  • 44. Mansouri S, Kalantar Neyestanaki D, Shokoohi M, Halimi S, Beigverdi R, Rezagholezadeh F, et al. Characterization of AmpC, CTX-M and MBLs types of beta-lactamases in clinical isolates of Klebsiella pneumoniae and Escherichia coli producing Extended Spectrum beta-lactamases in Kerman, Iran. Jundishapur J Microbiol. 2014; 7(2)[DOI][PubMed]
  • 45. Nordmann P, Poirel L, Dortet L. Rapid detection of carbapenemase-producing Enterobacteriaceae. Emerg Infect Dis. 2012; 18(9): 1503-7[DOI][PubMed]
  • 46. Pires J, Novais A, Peixe L. Blue-carba, an easy biochemical test for detection of diverse carbapenemase producers directly from bacterial cultures. J Clin Microbiol. 2013; 51(12): 4281-3[DOI][PubMed]
  • 47. Tsakris A, Kristo I, Poulou A, Themeli-Digalaki K, Ikonomidis A, Petropoulou D, et al. Evaluation of boronic acid disk tests for differentiating KPC-possessing Klebsiella pneumoniae isolates in the clinical laboratory. J Clin Microbiol. 2009; 47(2): 362-7[DOI][PubMed]
  • 48. Galani I, Rekatsina PD, Hatzaki D, Plachouras D, Souli M, Giamarellou H. Evaluation of different laboratory tests for the detection of metallo-beta-lactamase production in Enterobacteriaceae. J Antimicrob Chemother. 2008; 61(3): 548-53[DOI][PubMed]
  • 49. Cunningham SA, Noorie T, Meunier D, Woodford N, Patel R. Rapid and simultaneous detection of genes encoding Klebsiella pneumoniae carbapenemase (blaKPC) and New Delhi metallo-beta-lactamase (blaNDM) in Gram-negative bacilli. J Clin Microbiol. 2013; 51(4): 1269-71[DOI][PubMed]
  • 50. Nordmann P, Poirel L. Strategies for identification of carbapenemase-producing Enterobacteriaceae. J Antimicrob Chemother. 2013; 68(3): 487-9[DOI][PubMed]
  • 51. Vasoo S, Cunningham SA, Kohner PC, Mandrekar JN, Lolans K, Hayden MK, et al. Rapid and direct real-time detection of blaKPC and blaNDM from surveillance samples. J Clin Microbiol. 2013; 51(11): 3609-15[DOI][PubMed]
  • 52. Nijhuis R, Samuelsen O, Savelkoul P, van Zwet A. Evaluation of a new real-time PCR assay (Check-Direct CPE) for rapid detection of KPC, OXA-48, VIM, and NDM carbapenemases using spiked rectal swabs. Diagn Microbiol Infect Dis. 2013; 77(4): 316-20[DOI][PubMed]
  • 53. Giske CG, Libisch B, Colinon C, Scoulica E, Pagani L, Fuzi M, et al. Establishing clonal relationships between VIM-1-like metallo-beta-lactamase-producing Pseudomonas aeruginosa strains from four European countries by multilocus sequence typing. J Clin Microbiol. 2006; 44(12): 4309-15[DOI][PubMed]
  • 54. Maatallah M, Bakhrouf A, Habeeb MA, Turlej-Rogacka A, Iversen A, Pourcel C, et al. Four genotyping schemes for phylogenetic analysis of Pseudomonas aeruginosa: comparison of their congruence with multi-locus sequence typing. PLoS One. 2013; 8(12)[DOI][PubMed]
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