Archives of Clinical Infectious Diseases

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Seroprevalence of Toxoplasma gondii Infection in Patients with Alzheimer’s Disease

Mohammad Menati Rashno 1 , Shirzad Fallahi 2 , * , Farnaz Kheirandish 2 , Shahrokh Bagheri 3 , Mohammad Hassan Kayedi 2 and Mehdi Birjandi 4
Authors Information
1 Department of Biotechnology, Damghan Branch, Islamic Azad University, Damghan, IR Iran
2 Department of Medical Parasitology and Mycology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, IR Iran
3 Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, IR Iran
4 Department of Biostatistics, Lorestan University of Medical Sciences, Khorramabad, IR Iran
Article information
  • Archives of Clinical Infectious Diseases: July 2016, 11 (3); e60133
  • Published Online: June 26, 2016
  • Article Type: Research Article
  • Received: February 18, 2016
  • Revised: June 10, 2016
  • Accepted: June 12, 2016
  • DOI: 10.5812/archcid.37205

To Cite: Menati Rashno M, Fallahi S, Kheirandish F, Bagheri S, Kayedi M H, et al. Seroprevalence of Toxoplasma gondii Infection in Patients with Alzheimer’s Disease, Arch Clin Infect Dis. 2016 ; 11(3):e60133. doi: 10.5812/archcid.37205.

Copyright © 2016, Infectious Diseases and Tropical Medicine Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Motoya JG, Kovacs JA, Remington JS. Toxosplasma gondii. Principle and practice of infections diseases. 2005; 2: 3170-91
  • 2. Holliman RE, Johnson JD, Adams S, Pepper JR. Toxoplasmosis and heart transplantation. J Heart Lung Transplant. 1991; 10(4): 608-10[PubMed]
  • 3. Coelho RA, Kobayashi M, Carvalho LJ. Prevalence of IgG antibodies specific to Toxoplasma gondii among blood donors in Recife, Northeast Brazil. Rev Inst Med Trop Sao Paulo. 2003; 45(4): 229-31[PubMed]
  • 4. Jones JL, Ogunmodede F, Scheftel J, Kirkland E, Lopez A, Schulkin J, et al. Toxoplasmosis-related knowledge and practices among pregnant women in the United States. Infect Dis Obstet Gynecol. 2003; 11(3): 139-45[DOI][PubMed]
  • 5. Hill D, Dubey JP. Toxoplasma gondii: transmission, diagnosis and prevention. Clin Microbiol Infect. 2002; 8(10): 634-40[PubMed]
  • 6. Alvarado-Esquivel C, Torres-Castorena A, Liesenfeld O, Garcia-Lopez CR, Estrada-Martinez S, Sifuentes-Alvarez A, et al. Seroepidemiology of Toxoplasma gondii infection in pregnant women in rural Durango, Mexico. J Parasitol. 2009; 95(2): 271-4[DOI][PubMed]
  • 7. Carruthers VB, Suzuki Y. Effects of Toxoplasma gondii infection on the brain. Schizophr Bull. 2007; 33(3): 745-51[DOI][PubMed]
  • 8. Montoya JG, Liesenfeld O. Toxoplasmosis. Lancet. 2004; 363(9425): 1965-76[DOI][PubMed]
  • 9. Koseoglu E, Yazar S, Koc I. Is Toxoplasma gondii a causal agent in migraine? Am J Med Sci. 2009; 338(2): 120-2[DOI][PubMed]
  • 10. Miman O, Mutlu EA, Ozcan O, Atambay M, Karlidag R, Unal S. Is there any role of Toxoplasma gondii in the etiology of obsessive-compulsive disorder? Psychiatry Res. 2010; 177(1-2): 263-5[DOI][PubMed]
  • 11. Torrey EF, Bartko JJ, Lun ZR, Yolken RH. Antibodies to Toxoplasma gondii in patients with schizophrenia: a meta-analysis. Schizophr Bull. 2007; 33(3): 729-36[DOI][PubMed]
  • 12. Yazar S, Arman F, Yalcin S, Demirtas F, Yaman O, Sahin I. Investigation of probable relationship between Toxoplasma gondii and cryptogenic epilepsy. Seizure. 2003; 12(2): 107-9[PubMed]
  • 13. Henriquez SA, Brett R, Alexander J, Pratt J, Roberts CW. Neuropsychiatric disease and Toxoplasma gondii infection. Neuroimmunomodulation. 2009; 16(2): 122-33[DOI][PubMed]
  • 14. Tamer GS, Dundar D, Yalug I, Caliskan S, Yazar S, Aker A. The schizophrenia and Toxoplasma gondii connection: infectious, immune or both? Adv Ther. 2008; 25(7): 703-9[DOI][PubMed]
  • 15. Hermes G, Ajioka JW, Kelly KA, Mui E, Roberts F, Kasza K, et al. Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection. J Neuroinflammation. 2008; 5: 48[DOI][PubMed]
  • 16. Rozenfeld C, Martinez R, Seabra S, Sant'anna C, Goncalves JG, Bozza M, et al. Toxoplasma gondii prevents neuron degeneration by interferon-gamma-activated microglia in a mechanism involving inhibition of inducible nitric oxide synthase and transforming growth factor-beta1 production by infected microglia. Am J Pathol. 2005; 167(4): 1021-31[PubMed]
  • 17. Fallahi S, Mazar ZA, Ghasemian M, Haghighi A. Challenging loop-mediated isothermal amplification (LAMP) technique for molecular detection of Toxoplasma gondii. Asian Pac J Trop Med. 2015; 8(5): 366-72[DOI][PubMed]
  • 18. Kheirandish F, Sharafi AC, Kazemi B, Bandehpour M, Tarahi MJ, Khamesipour A. First molecular identification of leishmania species in a new endemic area of cutaneous leishmaniasis in lorestan, iran. Asian Pac J Trop Med. 2013; 6(9): 713-7[DOI]
  • 19. Badparva E, Nayebzadeh H, Barkhordari MH, Ezatpour B. Epidemiological study of strongyloides stercoralis with a comparative diagnostic approach, in lorestan, west of iran. Arch Clin Infect Dis. 2014; 9(2)
  • 20. Ho L, Sharma N, Blackman L, Festa E, Reddy G, Pasinetti GM. From proteomics to biomarker discovery in Alzheimer's disease. Brain Res Brain Res Rev. 2005; 48(2): 360-9[DOI][PubMed]
  • 21. Pregelj P. Involvement of cholesterol in the pathogenesis of Alzheimer's disease: role of statins. Psychiatr Danub. 2008; 20(2): 162-7[PubMed]
  • 22. Goodman G, Limbird L, Hardman J. The pharmacological basis of therapeutics. 2001; 10: 560-2
  • 23. Resende R, Moreira PI, Proenca T, Deshpande A, Busciglio J, Pereira C, et al. Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease. Free Radic Biol Med. 2008; 44(12): 2051-7[DOI][PubMed]
  • 24. Geldmacher DS, Whitehouse PJ. Differential diagnosis of Alzheimer's disease. Neurology. 1997; 48(5 Suppl 6)-9[PubMed]
  • 25. Tanzi RE, Bertram L. Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell. 2005; 120(4): 545-55[DOI][PubMed]
  • 26. Vepsalainen S. A molecular genetic study and expression-based analysis of risk factors of Alzheimer's disease. Department of neurology series of reports. 2007; 90: 119
  • 27. Dinamarca MC, Arrazola M, Toledo E, Cerpa WF, Hancke J, Inestrosa NC. Release of acetylcholinesterase (AChE) from beta-amyloid plaques assemblies improves the spatial memory impairments in APP-transgenic mice. Chem Biol Interact. 2008; 175(1-3): 142-9[DOI][PubMed]
  • 28. Chang CY, Liang HJ, Chow SY, Chen SM, Liu DZ. Hemorheological mechanisms in Alzheimer's disease. Microcirculation. 2007; 14(6): 627-34[DOI][PubMed]
  • 29. Fond G, Capdevielle D, Macgregor A, Attal J, Larue A, Brittner M, et al. [Toxoplasma gondii: a potential role in the genesis of psychiatric disorders]. Encephale. 2013; 39(1): 38-43[DOI][PubMed]
  • 30. Kusbeci OY, Miman O, Yaman M, Aktepe OC, Yazar S. Could Toxoplasma gondii have any role in Alzheimer disease? Alzheimer Dis Assoc Disord. 2011; 25(1): 1-3[DOI][PubMed]
  • 31. Badparva E, Kheirandish F, Ebrahimzade F. Prevalence of intestinal parasites in lorestan province, west of iran. Asian Pac J Trop Dis. 2014; 4: 728-32
  • 32. Kayedi MH, Lines JD, Haghdoost AA. Evaluation of the wash resistance of three types of manufactured insecticidal nets in comparison to conventionally treated nets. Acta Trop. 2009; 111(2): 192-6[DOI][PubMed]
  • 33. Kheirandish F, Tarahi M, Haghighi A, Nazemalhosseini-Mojarad E, Kheirandish M. Prevalence of intestinal parasites in bakery workers in khorramabad, lorestan iran. Iran J Parasitol. 2011; 6(4): 76-83[PubMed]
  • 34. Kheirandish F, Tarahi MJ, Ezatpour B. Prevalence of intestinal parasites among food handlers in Western Iran. Rev Inst Med Trop Sao Paulo. 2014; 56(2): 111-4[DOI][PubMed]
  • 35. Kheirandish F, Kayedi MH, Ezatpour B, Anbari K, Karimi Rouzbahani HR, Chegeni Sharafi A, et al. Seroprevalence of Human Fasciolosis in Pirabad, Lorestan Province, Western Iran. Iran J Parasitol. 2016; 11(1): 24-9[PubMed]
  • 36. Omrani VF, Fallahi S, Rostami A, Siyadatpanah A, Barzgarpour G, Mehravar S, et al. Prevalence of intestinal parasite infections and associated clinical symptoms among patients with end-stage renal disease undergoing hemodialysis. Infection. 2015; 43(5): 537-44[DOI][PubMed]
  • 37. Fallahi S, Rostami A, Mohammadi M, Ebrahimzadeh F, Pournia Y. Practical parasitology courses and infection with intestinal parasites in students. J Infect Public Health. 2016; [DOI][PubMed]
  • 38. Fallahi S, Kazemi B, Seyyed tabaei SJ, Bandehpour M, Lasjerdi Z, Taghipour N, et al. Comparison of the RE and B1 gene for detection of Toxoplasma gondii infection in children with cancer. Parasitol Int. 2014; 63(1): 37-41[DOI][PubMed]
  • 39. Arab-Mazar Z, Fallahi S, Koochaki A, Haghighi A, Seyyed Tabaei SJ. Immunodiagnosis and molecular validation of Toxoplasma gondii-recombinant dense granular (GRA) 7 protein for the detection of toxoplasmosis in patients with cancer. Microbiol Res. 2016; 183: 53-9[DOI][PubMed]
  • 40. Fallahi S, Seyyed Tabaei SJ, Pournia Y, Zebardast N, Kazemi B. Comparison of loop-mediated isothermal amplification (LAMP) and nested-PCR assay targeting the RE and B1 gene for detection of Toxoplasma gondii in blood samples of children with leukaemia. Diagn Microbiol Infect Dis. 2014; 79(3): 347-54[DOI][PubMed]
  • 41. Gajewski PD, Falkenstein M, Hengstler JG, Golka K. Toxoplasma gondii impairs memory in infected seniors. Brain Behav Immun. 2014; 36: 193-9[DOI][PubMed]
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