Archives of Clinical Infectious Diseases

Published by: Kowsar

The Effectiveness of Ozone Therapy in Chronic Osteomyelitis: A Randomized Controlled Clinical Trial

Bahram Naderi Nabi 1 , Abbas Sedighinejad 2 , Ahmad Reza Mirbolouk 3 , Farnoush Farzi 4 , Mohammad Haghighi 4 , Zahra Atrkarroushan 5 , Gelareh Biazar 6 , * and Amer Chohdary 7
Authors Information
1 MD, Associate Professor of Anesthesiology, Fellowship of Anesthesia and Pain (FIPP), Anesthesiology Department, Anesthesiology Research Center, Guilan University of Medical Sciences, Rasht, Iran
2 MD, Associate Professor of Anesthesiology, Fellowship of Anesthesia in Cardiac Surgery, Anesthesiology Research Center, Guilan University of Medical Sciences (GUMS), Rasht, Iran
3 MD, Associate Professor of Orthopedie ,Guilan University of Medical Sciences (GUMS), Orthopedic Research Center, Poursina Hospital, Rasht, Iran
4 MD, Associate Professor of Anesthesiology, Anesthesiology Department, Anesthesiology Research Center, Guilan University of Medical Sciences, Rasht, Iran
5 PhD, Assistant Professor of Biostatistic, Guilan University of Medical Sciences (GUMS), Rasht, Iran
6 MD, Assistant Professor of Anesthesiology, Anesthesiology Research Center, Guilan University of Medical Sciences (GUMS), Rasht, Iran
7 MD, Resident of Anesthesiology, Anesthesiology Research Center, Guilan University of Medical Sciences (GUMS), Rasht, Iran
Article information
  • Archives of Clinical Infectious Diseases: April 2018, 13 (2); e61320
  • Published Online: April 24, 2018
  • Article Type: Research Article
  • Received: April 17, 2017
  • Revised: September 4, 2017
  • Accepted: September 17, 2017
  • DOI: 10.5812/archcid.61320

To Cite: Naderi Nabi B, Sedighinejad A, Mirbolouk A R, Farzi F, Haghighi M, et al. The Effectiveness of Ozone Therapy in Chronic Osteomyelitis: A Randomized Controlled Clinical Trial, Arch Clin Infect Dis. 2018 ; 13(2):e61320. doi: 10.5812/archcid.61320.

Abstract
Copyright © 2018, Archives of Clinical Infectious Diseases. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Barshes NR, Mindru C, Ashong C, Rodriguez-Barradas M, Trautner BW. Treatment Failure and Leg Amputation Among Patients With Foot Osteomyelitis. Int J Low Extrem Wounds. 2016;15(4):303-12. doi: 10.1177/1534734616661058. [PubMed: 27581112].
  • 2. Garwood CS, Kim PJ. Relevance of Osteomyelitis to Clinical Practice. Osteomyelitis of the Foot and Ankle. Springer; 2015.
  • 3. Oguz E, Ekinci S, Eroglu M, Bilgic S, Koca K, Durusu M, et al. Evaluation and comparison of the effects of hyperbaric oxygen and ozonized oxygen as adjuvant treatments in an experimental osteomyelitis model. J Surg Res. 2011;171(1):e61-8. doi: 10.1016/j.jss.2011.06.029. [PubMed: 21920551].
  • 4. Walter G, Kemmerer M, Kappler C, Hoffmann R. Treatment algorithms for chronic osteomyelitis. Dtsch Arztebl Int. 2012;109(14):257-64. doi: 10.3238/arztebl.2012.0257. [PubMed: 22536302]. [PubMed Central: PMC3336146].
  • 5. Geurts J, Hohnen A, Vranken T, Moh P. Treatment strategies for chronic osteomyelitis in low- and middle-income countries: systematic review. Trop Med Int Health. 2017;22(9):1054-62. doi: 10.1111/tmi.12921. [PubMed: 28665557].
  • 6. Mosqueira JRM. Septic arthritis due to underlying Scedosporium apiospermum chronic osteomyelitis. Report of one case and brief review of the literature. Journal of Microbiology and Infectious DiseasesJ Microbiol Infect Dis. 2017;6(4):192-6. doi: 10.5799/jmid.vi.328943.
  • 7. Leung AH, Hawthorn BR, Simpson AH. The Effectiveness of Local Antibiotics in Treating Chronic Osteomyelitis in a Cohort of 50 Patients with an Average of 4 Years Follow-Up. Open Orthop J. 2015;9:372-8. doi: 10.2174/1874325001509010372. [PubMed: 26322143]. [PubMed Central: PMC4549894].
  • 8. Tuchscherr L, Kreis CA, Hoerr V, Flint L, Hachmeister M, Geraci J, et al. Staphylococcus aureus develops increased resistance to antibiotics by forming dynamic small colony variants during chronic osteomyelitis. J Antimicrob Chemother. 2016;71(2):438-48. doi: 10.1093/jac/dkv371. [PubMed: 26589581].
  • 9. Conterno LO, Turchi MD. Antibiotics for treating chronic osteomyelitis in adults. Cochrane Database Syst Rev. 2013;(9). CD004439. doi: 10.1002/14651858.CD004439.pub3. [PubMed: 24014191].
  • 10. Turkmen A. Chronic hepatitis B and ozone therapy. J Case Rep Pract. 2015;3(2):38-9.
  • 11. Rimini D, Molinari F, Liboni W, Simonetti V, Franzini M. The speed of reinfusion affects the vascular system during ozone major autohemotherapy. Ozone Ther. 2017;1(3):56-60. doi: 10.4081/ozone.2016.6477.
  • 12. Franzini M, Valdenassi L, Ionita G. First evaluations of oxygen-ozone therapy in antibiotic-resistant infections. Ozone Ther. 2016;1(1):5-7. doi: 10.4081/ozone.2016.5838.
  • 13. Re L, Malcangi G, Mercante O, Gagliardi C, Rampoldi N. Stevens-Johnson syndrome treated with ozone hemo therapy: A case report. Int J Med Pharm Case Reports. 2015;4(4):92-6. doi: 10.9734/ijmpcr/2015/18947.
  • 14. Hashemi M, Naderi Nabi B, Saberi A, Sedighinejad A, Haghighi M, Farzi F, et al. The comparison between two methods for the relief of knee osteoarthritis pain: Radiofrequency and intra-periarticular Ozone injection: A clinical trial study. Int J Med Res Health Sci. 2016;5(7S):539-46.
  • 15. Bocci V, Borrelli E, Zanardi I, Travagli V. The usefulness of ozone treatment in spinal pain. Drug Des Devel Ther. 2015;9:2677-85. doi: 10.2147/DDDT.S74518. [PubMed: 26028964]. [PubMed Central: PMC4440430].
  • 16. He W, Yu F, Duan P. Comments on "Comparison of the influence of ozone and laser therapies on pain, swelling, and trismus following impacted third-molar surgery". Lasers Med Sci. 2015;30(5):1627. doi: 10.1007/s10103-013-1476-1. [PubMed: 24292198].
  • 17. Borrelli E, De Monte A, Bocci V. Oxygen ozone therapy in the integrated treatment of chronic ulcer: a case series report. Int J Recent Sci Res. 2015;6(5):4132-6.
  • 18. Akdeniz SS, Beyler E, Korkmaz Y, Yurtcu E, Ates U, Araz K, et al. The effects of ozone application on genotoxic damage and wound healing in bisphosphonate-applied human gingival fibroblast cells. Clin Oral Investig. 2017;22(2):867–73.
  • 19. Koyama R, Okuda KI, Matsushita K, Beppu M, Mizunoe Y. Antimicrobial and antibiofilm effects of ozonated water for prevention and treatment of bone and joint infections. J St. Marianna Univ. 2015;6(1):1-7. doi: 10.17264/stmarieng.6.1.
  • 20. Invernizzi M, Stagno D, Card S, Grana E, Picelli A, Smania N, et al. Safety of intra-articular Oxygen-Ozone therapy compared to intra-articular sodium hyaluronate in knee osteoarthritis: A randomized single blind pilot study. J Phys Med Rehabil. 2017;5(1). doi: 10.4172/2329-9096.1000385.
  • 21. Mani A, Shukla P, Patel R, Bhople T, Mani S. Ozone therapy in Periodontics-A review. J Med Sci Clin Res. 2014;2(12):3352-8.
  • 22. Murphy K, Elias G, Steppan J, Boxley C, Balagurunathan K, Victor X, et al. Percutaneous Treatment of Herniated Lumbar Discs with Ozone: Investigation of the Mechanisms of Action. J Vasc Interv Radiol. 2016;27(8):1242-1250 e3. doi: 10.1016/j.jvir.2016.04.012. [PubMed: 27363296].
  • 23. Aaron J. Smith , John Oertle J, Dan Warren D, Dino Prato D. Ozone therapy: A critical physiological and diverse clinical evaluation with regard to immune modulation, anti-infectious properties, anti-cancer potential, and impact on anti-oxidant enzymes. Open J Mol Integr Physiol. 2015;5:37-48. doi: 10.4236/ojmip.2015.53004.
  • 24. Manoto SL, Maepa MJ, Motaung SK. Medical ozone therapy as a potential treatment modality for regeneration of damaged articular cartilage in osteoarthritis. Saudi J Biol Sci. 2018;25(4):672-9. doi: 10.1016/j.sjbs.2016.02.002. [PubMed: 29736142]. [PubMed Central: PMC5935866].
  • 25. Shah P, Shyam AK, Shah S. Adjuvant combined ozone therapy for extensive wound over tibia. Indian J Orthop. 2011;45(4):376-9. doi: 10.4103/0019-5413.80332. [PubMed: 21772635]. [PubMed Central: PMC3134027].
  • 26. Estrela C, Estrela CR, Decurcio Dde A, Silva JA, Bammann LL. Antimicrobial potential of ozone in an ultrasonic cleaning system against Staphylococcus aureus. Braz Dent J. 2006;17(2):134-8. doi: 10.1590/S0103-64402006000200010. [PubMed: 16924341].
  • 27. Dhingra S, Raghavan V, Kumar R. Ozone in oral medicine. Guident. 2014;7(7).
  • 28. Elvis AM, Ekta JS. Ozone therapy: A clinical review. J Nat Sci Biol Med. 2011;2(1):66-70. doi: 10.4103/0976-9668.82319. [PubMed: 22470237]. [PubMed Central: PMC3312702].
  • 29. Turkmen A, Kesici S, Keles E, Denizli E, Buyukyildirim A, Kesici U. Ozone treatment in patient with multiple traumas. Case Study Case Rep. 2015;5(1):25-8.
  • 30. Irban A, Arel Gereli A, Aydinlar EI, Karyemez PE, Luleci N, Suyen GG. The effect of ozone therapy on experimental bone fracture healing in rats. Int Res J Public Environ Health. 2015;2(10):159-66. doi: 10.15739/irjpeh.034.
  • 31. Ozdemir H, Toker H, Balci H, Ozer H. Effect of ozone therapy on autogenous bone graft healing in calvarial defects: a histologic and histometric study in rats. J Periodontal Res. 2013;48(6):722-6. doi: 10.1111/jre.12060. [PubMed: 23452156].
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