Archives of Clinical Infectious Diseases

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The Association Between Serum Level of Vitamin D and Asymptomatic Bacteriuria in Pre- and Postmenopausal Women Evaluated During 2011 - 2016

Mehrdad Haghighi 1 , 2 , * , Simindokht Shoaee 1 , Mostafa Alavi Moghaddam 2 , Mohammad Sistanizad 2 and Mehran Nikbakht 3
Authors Information
1 Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
2 Department of Infectious Diseases, Imam Hossein Teaching and Medical Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
3 Infectious Diseases and Tropical Medicine Resident of Tehran University of Medical Sciences, Imam Khomeini Teaching and Medical Hospital, Tehran, IR Iran
Article information
  • Archives of Clinical Infectious Diseases: July 2017, 12 (3); e62134
  • Published Online: July 31, 2017
  • Article Type: Research Article
  • Received: April 9, 2016
  • Revised: March 13, 2017
  • Accepted: March 14, 2017
  • DOI: 10.5812/archcid.62134

To Cite: Haghighi M, Shoaee S, Alavi Moghaddam M, Sistanizad M, Nikbakht M. The Association Between Serum Level of Vitamin D and Asymptomatic Bacteriuria in Pre- and Postmenopausal Women Evaluated During 2011 - 2016, Arch Clin Infect Dis. 2017 ; 12(3):e62134. doi: 10.5812/archcid.62134.

Copyright © 2017, Archives of Clinical Infectious Diseases. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Nicolle LE, Bradley S, Colgan R, Rice JC, Schaeffer A, Hooton TM, et al. Infectious Diseases Society of America guidelines for the diagnosis and treatment of asymptomatic bacteriuria in adults. Clin Infect Dis. 2005; 40(5): 643-54[DOI][PubMed]
  • 2. Asscher AW, Sussman M, Waters WE, Evans JA, Campbell H, Evans KT, et al. Asymptomatic significant bacteriuria in the non-pregnant woman. II. Response to treatment and follow-up. Br Med J. 1969; 1(5647): 804-6[PubMed]
  • 3. Harding GK, Zhanel GG, Nicolle LE, Cheang M, Manitoba Diabetes Urinary Tract Infection Study G. Antimicrobial treatment in diabetic women with asymptomatic bacteriuria. N Engl J Med. 2002; 347(20): 1576-83[DOI][PubMed]
  • 4. Hooton TM, Scholes D, Stapleton AE, Roberts PL, Winter C, Gupta K, et al. A prospective study of asymptomatic bacteriuria in sexually active young women. N Engl J Med. 2000; 343(14): 992-7[DOI][PubMed]
  • 5. Bengtsson C, Bengtsson U, Bjorkelund C, Lincoln K, Sigurdsson JA. Bacteriuria in a population sample of women: 24-year follow-up study. Results from the prospective population-based study of women in Gothenburg, Sweden. Scand J Urol Nephrol. 1998; 32(4): 284-9[PubMed]
  • 6. Nicolle LE. Asymptomatic bacteriuria: when to screen and when to treat. Infect Dis Clin North Am. 2003; 17(2): 367-94[PubMed]
  • 7. Nseir W, Taha M, Nemarny H, Mograbi J. The association between serum levels of vitamin D and recurrent urinary tract infections in premenopausal women. Int J Infect Dis. 2013; 17(12)-4[DOI][PubMed]
  • 8. Khajavi A, Amirhakimi GH. The rachitic lung. Pulmonary findings in 30 infants and children with malnutritional rickets. Clin Pediatr (Phila). 1977; 16(1): 36-8[DOI][PubMed]
  • 9. Cannell JJ, Vieth R, Umhau JC, Holick MF, Grant WB, Madronich S, et al. Epidemic influenza and vitamin D. Epidemiol Infect. 2006; 134(6): 1129-40[DOI][PubMed]
  • 10. Ginde AA, Mansbach JM, Camargo CJ. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2009; 169(4): 384-90[DOI][PubMed]
  • 11. Rook GA, Steele J, Fraher L, Barker S, Karmali R, O'Riordan J, et al. Vitamin D3, gamma interferon, and control of proliferation of Mycobacterium tuberculosis by human monocytes. Immunology. 1986; 57(1): 159-63[PubMed]
  • 12. Crowle AJ, Ross EJ, May MH. Inhibition by 1,25(OH)2-vitamin D3 of the multiplication of virulent tubercle bacilli in cultured human macrophages. Infect Immun. 1987; 55(12): 2945-50[PubMed]
  • 13. Hertting O, Holm A, Luthje P, Brauner H, Dyrdak R, Jonasson AF, et al. Vitamin D induction of the human antimicrobial Peptide cathelicidin in the urinary bladder. PLoS One. 2010; 5(12)[DOI][PubMed]
  • 14. Hooton TM, Scholes D, Hughes JP, Winter C, Roberts PL, Stapleton AE, et al. A prospective study of risk factors for symptomatic urinary tract infection in young women. N Engl J Med. 1996; 335(7): 468-74[DOI][PubMed]
  • 15. Jackson SL, Boyko EJ, Scholes D, Abraham L, Gupta K, Fihn SD. Predictors of urinary tract infection after menopause: a prospective study. Am J Med. 2004; 117(12): 903-11[DOI][PubMed]
  • 16. Yetley EA. Assessing the vitamin D status of the US population. Am J Clin Nutr. 2008; 88(2): 558S-64S[PubMed]
  • 17. Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, et al. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int. 2009; 20(11): 1807-20[DOI][PubMed]
  • 18. Hypponen E, Power C. Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors. Am J Clin Nutr. 2007; 85(3): 860-8[PubMed]
  • 19. Declaration of Helsinki. Recommendations guiding doctors in clinical research. Adopted by the World Medical Association in 1964. Wis Med J. 1967; 66(1): 25-6[PubMed]
  • 20. Bikle DD. Vitamin D and the immune system: role in protection against bacterial infection. Curr Opin Nephrol Hypertens. 2008; 17(4): 348-52[DOI][PubMed]
  • 21. Lorente F, Fontan G, Jara P, Casas C, Garcia-Rodriguez MC, Ojeda JA. Defective neutrophil motility in hypovitaminosis D rickets. Acta Paediatr Scand. 1976; 65(6): 695-9[PubMed]
  • 22. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006; 311(5768): 1770-3[DOI][PubMed]
  • 23. Chromek M, Slamova Z, Bergman P, Kovacs L, Podracka L, Ehren I, et al. The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection. Nat Med. 2006; 12(6): 636-41[DOI][PubMed]
  • 24. Ovunc Hacihamdioglu D, Altun D, Hacihamdioglu B, Cekmez F, Aydemir G, Kul M, et al. The Association between Serum 25-Hydroxy Vitamin D Level and Urine Cathelicidin in Children with a Urinary Tract Infection. J Clin Res Pediatr Endocrinol. 2016; 8(3): 325-9[DOI][PubMed]
  • 25. van der Starre WE, van Nieuwkoop C, Thomson U, Zijderveld-Voshart MS, Koopman JP, van der Reijden TJ, et al. Urinary proteins, vitamin D and genetic polymorphisms as risk factors for febrile urinary tract infection and relation with bacteremia: a case control study. PLoS One. 2015; 10(3)[DOI][PubMed]
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