Archives of Clinical Infectious Diseases

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Cytokine Profiles in Acute Brucellosis, Compared with Those in Other Febrile Illnesses

Anahita Sanaei Dashti 1 , * , Abdollah Karimi 2 , Babak Elyasi 2 , Ahmad Reza Shamshiri 3 , Seyed Abdolmajid Shoja 1 and Maryam Shamshiri 2
Authors Information
1 Shiraz HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran
2 Pediatric Infectious Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Dental Research Center, Dentistry Research Institute, Department of Community Oral Health, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
Article information
  • Archives of Clinical Infectious Diseases: October 2017, 12 (4); e66077
  • Published Online: September 27, 2017
  • Article Type: Research Article
  • Received: May 1, 2016
  • Revised: March 16, 2017
  • Accepted: April 4, 2017
  • DOI: 10.5812/archcid.66077

To Cite: Sanaei Dashti A, Karimi A, Elyasi B, Shamshiri A R, Shoja S A, et al. Cytokine Profiles in Acute Brucellosis, Compared with Those in Other Febrile Illnesses, Arch Clin Infect Dis. 2017 ; 12(4):e66077. doi: 10.5812/archcid.66077.

Copyright © 2017, Archives of Clinical Infectious Diseases. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Mostafavi E, Asmand M. Trend of brucellosis in Iran from 1991 to 2008. Iran J Epidemiol. 2012;8(1):94-101.
  • 2. Demirdag K, Ozden M, Kalkan A, Godekmerdan A, Sirri Kilic S. Serum cytokine levels in patients with acute brucellosis and their relation to the traditional inflammatory markers. FEMS Immunol Med Microbiol. 2003;39(2):149-53. [PubMed: 14625098].
  • 3. Galanakis E, Makis A, Bourantas KL, Papadopoulou ZL. Interleukin-3 and interleukin-4 in childhood brucellosis. Infection. 2002;30(1):33-4. [PubMed: 11876513].
  • 4. Zhan Y, Cheers C. Endogenous interleukin-12 is involved in resistance to Brucella abortus infection. Infect Immun. 1995;63(4):1387-90. [PubMed: 7890399].
  • 5. Golding B, Scott DE, Scharf O, Huang LY, Zaitseva M, Lapham C, et al. Immunity and protection against Brucella abortus. Microbes Infect. 2001;3(1):43-8. [PubMed: 11226853].
  • 6. Bravo MJ, de Dios Colmenero J, Alonso A, Caballero A. Polymorphisms of the interferon gamma and interleukin 10 genes in human brucellosis. Eur J Immunogenet. 2003;30(6):433-5. [PubMed: 14675398].
  • 7. Rasouli M, Kiany S, Alborzi A. Polymorphism in the first intron of interferon gamma gene (+ 874T,A) in Iranian patients with brucellosis. Iran J Immunol. 2005;2(4):226-31.
  • 8. Jiang X, Baldwin CL. Effects of cytokines on intracellular growth of Brucella abortus. Infect Immun. 1993;61(1):124-34. [PubMed: 8418034].
  • 9. Fernandes DM, Baldwin CL. Interleukin-10 downregulates protective immunity to Brucella abortus. Infect Immun. 1995;63(3):1130-3. [PubMed: 7868238].
  • 10. Zhan Y, Liu Z, Cheers C. Tumor necrosis factor alpha and interleukin-12 contribute to resistance to the intracellular bacterium Brucella abortus by different mechanisms. Infect Immun. 1996;64(7):2782-6. [PubMed: 8698508].
  • 11. Scharf O, Agranovich I, Lee K, Eller NL, Levy L, Inman J, et al. Ontogeny of Th1 memory responses against a Brucella abortus conjugate. Infect Immun. 2001;69(9):5417-22. [PubMed: 11500412].
  • 12. Ahmed K, Al-Matrouk KA, Martinez G, Oishi K, Rotimi VO, Nagatake T. Increased serum levels of interferon-gamma and interleukin-12 during human brucellosis. Am J Trop Med Hyg. 1999;61(3):425-7. [PubMed: 10497984].
  • 13. Kazak E, Akalin H, Yilmaz E, Heper Y, Mistik R, Sinirtas M, et al. Brucellosis, a retrospective evaluation of 164 cases. Singapore Med J. 2016;57(11):624-9. doi: 10.11622/smedj.2015163. [PubMed: 26768063].
  • 14. Sanaei Dashti A, Karimi A. Skeletal involvement of Brucella melitensis in children, A systematic review. Iran J Med Sci. 2013;38(4):286-92. [PubMed: 24293781].
  • 15. Tripp CS, Wolf SF, Unanue ER. Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc Natl Acad Sci U S A. 1993;90(8):3725-9. [PubMed: 8097322].
  • 16. Dornand J, Gross A, Lafont V, Liautard J, Oliaro J, Liautard JP. The innate immune response against Brucella in humans. Vet Microbiol. 2002;90(1-4):383-94. [PubMed: 12414158].
  • 17. Sypek JP, Chung CL, Mayor SE, Subramanyam JM, Goldman SJ, Sieburth DS, et al. Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J Exp Med. 1993;177(6):1797-802. [PubMed: 8098733].
  • 18. Giambartolomei GH, Delpino MV, Cahanovich ME, Wallach JC, Baldi PC, Velikovsky CA, et al. Diminished production of T helper 1 cytokines correlates with T cell unresponsiveness to Brucella cytoplasmic proteins in chronic human brucellosis. J Infect Dis. 2002;186(2):252-9. doi: 10.1086/341449. [PubMed: 12134263].
  • 19. Pappas G, Akritidis N, Bosilkovski M, Tsianos E. Brucellosis. N Engl J Med. 2005;352(22):2325-36. doi: 10.1056/NEJMra050570. [PubMed: 15930423].
  • 20. Zhan Y, Cheers C. Endogenous gamma interferon mediates resistance to Brucella abortus infection. Infect Immun. 1993;61(11):4899-901. [PubMed: 8406893].
  • 21. Hsieh CS, Macatonia SE, O'Garra A, Murphy KM. Pathogen-induced Th1 phenotype development in CD4+ alpha beta-TCR transgenic T cells is macrophage dependent. Int Immunol. 1993;5(4):371-82. [PubMed: 8494824].
  • 22. Refik M, Mehmet N, Durmaz R, Ersoy Y. Cytokine profile and nitric oxide levels in sera from patients with brucellosis. Braz J Med Biol Res. 2004;37(11):1659-63. [PubMed: 15517081].
  • 23. Akbulut H, Celik I, Akbulut A. Cytokine levels in patients with brucellosis and their relations with the treatment. Indian J Med Microbiol. 2007;25(4):387-90. [PubMed: 18087091].
  • 24. Rafiei A, Ardestani SK, Kariminia A, Keyhani A, Mohraz M, Amirkhani A. Dominant Th1 cytokine production in early onset of human brucellosis followed by switching towards Th2 along prolongation of disease. J Infect. 2006;53(5):315-24. doi: 10.1016/j.jinf.2005.11.024. [PubMed: 16488475].

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