Archives of Clinical Infectious Diseases

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Oxamflatin Induces E-cadherin Expression in HeLa Cervical Carcinoma Cells

Ebrahim Faghihloo 1 , * , Mojdeh Hakemi Vala 1 , Gita Eslami 1 and Hossein Goudarzi 1
Authors Information
1 Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Article information
  • Archives of Clinical Infectious Diseases: October 2018, 13 (5); e66977
  • Published Online: September 12, 2018
  • Article Type: Research Article
  • Received: February 3, 2018
  • Accepted: July 8, 2018
  • DOI: 10.5812/archcid.66977

To Cite: Faghihloo E, Hakemi Vala M, Eslami G, Goudarzi H. Oxamflatin Induces E-cadherin Expression in HeLa Cervical Carcinoma Cells, Arch Clin Infect Dis. 2018 ; 13(5):e66977. doi: 10.5812/archcid.66977.

Copyright © 2018, Archives of Clinical Infectious Diseases. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Cancer Genome Atlas Research Network; Albert Einstein College of Medicine; Analytical Biological Services; Barretos Cancer Hospital; Baylor College of Medicine; Beckman Research Institute of City of Hope, et al. Integrated genomic and molecular characterization of cervical cancer. Nature. 2017;543(7645):378-84. doi: 10.1038/nature21386. [PubMed: 28112728]. [PubMed Central: PMC5354998].
  • 2. Kumar RV, Bhasker S. Optimizing cervical cancer care in resource-constrained developing countries by tailoring community prevention and clinical management protocol. J Cancer Policy. 2014;2(2):63-73. doi: 10.1016/j.jcpo.2013.11.002.
  • 3. Elrefaey S, Massaro MA, Chiocca S, Chiesa F, Ansarin M. HPV in oropharyngeal cancer: The basics to know in clinical practice. Acta Otorhinolaryngol Ital. 2014;34(5):299-309. [PubMed: 25709145]. [PubMed Central: PMC4299160].
  • 4. Duenas-Gonzalez A, Lizano M, Candelaria M, Cetina L, Arce C, Cervera E. Epigenetics of cervical cancer. An overview and therapeutic perspectives. Mol Cancer. 2005;4:38. doi: 10.1186/1476-4598-4-38. [PubMed: 16248899]. [PubMed Central: PMC1291396].
  • 5. Marks P, Rifkind RA, Richon VM, Breslow R, Miller T, Kelly WK. Histone deacetylases and cancer: Causes and therapies. Nat Rev Cancer. 2001;1(3):194-202. doi: 10.1038/35106079. [PubMed: 11902574].
  • 6. Wang YL, Liui HL, Fu RG, Wang ZW, Ren HT, Dai ZJ, et al. HDAC inhibitor oxamflatin induces morphological changes and has strong cytostatic effects in ovarian cancer cell lines. Curr Mol Med. 2016;16(3):232-42. doi: 10.2174/1566524016666160225151408. [PubMed: 26917266].
  • 7. Liu YN, Lee WW, Wang CY, Chao TH, Chen Y, Chen JH. Regulatory mechanisms controlling human E-cadherin gene expression. Oncogene. 2005;24(56):8277-90. doi: 10.1038/sj.onc.1208991. [PubMed: 16116478].
  • 8. Aghdassi A, Sendler M, Guenther A, Mayerle J, Behn CO, Heidecke CD, et al. Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer. Gut. 2012;61(3):439-48. doi: 10.1136/gutjnl-2011-300060. [PubMed: 22147512].
  • 9. Faghihloo E, Akbari A, Adjaminezhad-Fard F, Mokhtari-Azad T. Transcriptional regulation of E-cadherin and oncoprotein E7 by valproic acid in HPV positive cell lines. Iran J Basic Med Sci. 2016;19(6):601-7. [PubMed: 27482340]. [PubMed Central: PMC4951598].
  • 10. Mateen S, Raina K, Agarwal C, Chan D, Agarwal R. Silibinin synergizes with histone deacetylase and DNA methyltransferase inhibitors in upregulating E-cadherin expression together with inhibition of migration and invasion of human non-small cell lung cancer cells. J Pharmacol Exp Ther. 2013;345(2):206-14. doi: 10.1124/jpet.113.203471. [PubMed: 23461975]. [PubMed Central: PMC3629797].
  • 11. Deep G, Gangar SC, Agarwal C, Agarwal R. Role of E-cadherin in antimigratory and antiinvasive efficacy of silibinin in prostate cancer cells. Cancer Prev Res (Phila). 2011;4(8):1222-32. doi: 10.1158/1940-6207.CAPR-10-0370. [PubMed: 21546539]. [PubMed Central: PMC3151351].
  • 12. Faghihloo E, Sadeghizadeh M, Shahmahmoodi S, Mokhtari-Azad T. Transcriptional suppression of E-cadherin by HPV-16 E6 and E7 oncogenes is independent of hypermethylation of E-cadherin promoter. Iran Red Crescent Med J. 2016;19(2). doi: 10.5812/ircmj.30434.
  • 13. D'Costa ZJ, Jolly C, Androphy EJ, Mercer A, Matthews CM, Hibma MH. Transcriptional repression of E-cadherin by human papillomavirus type 16 E6. PLoS One. 2012;7(11). e48954. doi: 10.1371/journal.pone.0048954. [PubMed: 23189137]. [PubMed Central: PMC3506579].
  • 14. Caberg JH, Hubert PM, Begon DY, Herfs MF, Roncarati PJ, Boniver JJ, et al. Silencing of E7 oncogene restores functional E-cadherin expression in human papillomavirus 16-transformed keratinocytes. Carcinogenesis. 2008;29(7):1441-7. doi: 10.1093/carcin/bgn145. [PubMed: 18566017].

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