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Crimean-Congo Hemorrhagic Fever

AUTHORS

Masoud Mardani , *

How to Cite: Mardani M. Crimean-Congo Hemorrhagic Fever, Arch Clin Infect Dis. Online ahead of Print ; 7(1):36-42.

ARTICLE INFORMATION

Archives of Clinical Infectious Diseases: 7 (1); 36-42
Article Type: Review Article

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Abstract

Abstract: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral disease reported from more than 30 countries in Africa, Asia, South-East Europe, and the Middle East. Laboratory findings include prolonged prothrombin, bleeding, and activated partial thromboplastin times. Diagnostic methods include antibody detection by enzyme-linked immunosorbent assay (ELISA), virus isolation, antigen detection, and polymerase chain reaction (PCR). The mainstay of treatment is supportive, with carefulmaintenance of fluid and electrolyte balance, circulatory volume, and blood pressure. There is no controlled study evaluating oral versus intravenous ribavirin in treating CCHF patients, but few studies have evaluated oral ribavirin. This article reviews the epidemiology, pathogenesis, clinical manifestations, diagnosis, treatment, prevention, and prognosis of CCHF with especial focus on oral ribavirin as the only choice of medical treatment.

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© 0, Archives of Clinical Infectious Diseases. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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