Inducible Clindamycin Resistance in Clinical Isolates of <italic>Staphylococcus aureus</italic>

Abdolmajid Ghasemian; Shahin Najar Peerayeh; Bita Bakhshi; Mohsen Mirzaee

doi:10.5812/archcid.16218

Inducible Clindamycin Resistance in Clinical Isolates of Staphylococcus aureus

Abdolmajid Ghasemian ¹ , Shahin Najar Peerayeh ^{1
, *} , Bita Bakhshi ¹ and Mohsen Mirzaee ¹

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¹ Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IR Iran

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Archives of Clinical Infectious Diseases: 9 (2); 16218
Published Online: January 24, 2014
Article Type: Research Article
Received: November 15, 2013
Accepted: December 9, 2013
DOI: 10.5812/archcid.16218

To Cite: Ghasemian A, Najar Peerayeh S, Bakhshi B, Mirzaee M. Inducible Clindamycin Resistance in Clinical Isolates of Staphylococcus aureus , Arch Clin Infect Dis. Online ahead of Print ; 9(2):16218. doi: 10.5812/archcid.16218.

Abstract

Materials and Methods: A total of 209 clinical S. aureus isolates were collected and identified by conventional phenotypic tests. Antibiotic susceptibility pattern was detected by disc diffusion method. D-test was done using clindamycin (2 ?g) and erythromycin (15 ?g) discs according to the protocols of Clinical and Laboratory Standards Institute (CLSI). To detect methicillin resistant Staphylococcus aureus (MRSA), oxacillin disc was used and the results were confirmed by detection of mecA gene.

Results: Of all 209 clinical S. aureus isolates, 207 (99%) were resistant to amoxicillin. All isolates were susceptible to vancomycin and linezolid. The rate of clindamycin inducible resistance was 4% (n = 8). This phenotype was not observed in MRSA strains. There was no significant difference between methicillin resistant and susceptible strains. Resistance to clindamycin and erythromycin was higher in MRSA strains. D⁺ phenotype was detected in 1 (1%) of all isolates. Methicillin resistance was detected in 66 (32%) isolates by oxacillin disc and mecA gene was detected by PCR.

© 2014, Archives of Clinical Infectious Diseases. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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Inducible Clindamycin Resistance in Clinical Isolates of Staphylococcus aureus

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Inducible Clindamycin Resistance in Clinical Isolates of Staphylococcus aureus

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