Cite Score:
0.73
CITE SCORE SCOPUS

Survey of Association Between Helicobacter Pylori and Hepatocellular Carcinoma in the Specimens Derived from Health Centers of Shahid Beheshti University

AUTHORS

Mahrokhsar Fotouhi 1 , Gita Eslami 2 , * , Habibolah Peirovi 3 , Mohammad Hashemibahramani 4 , Masoumeh Douraghi 2 , Elahe Ahmadzadeh 3

1 Islamic Azad University, Tonekabon Branch, Tonekabon, IR Iran

2 Department of Microbiology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran

3 Nanomedicine and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran

4 Department of Pathology, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran

How to Cite: Fotouhi M, Eslami G, Peirovi H, Hashemibahramani M, Douraghi M, et al. Survey of Association Between Helicobacter Pylori and Hepatocellular Carcinoma in the Specimens Derived from Health Centers of Shahid Beheshti University, Arch Clin Infect Dis. Online ahead of Print ; 6(1):31-4.

ARTICLE INFORMATION

Archives of Clinical Infectious Diseases: 6 (1); 31-4
Article Type: Research Article

Crossmark

CHEKING

READ FULL TEXT
Abstract

Prior investigators demonstrated Helicobacter pylori as a risk factor of liver diseases. In this study association between H. pylori and hepatocellular carcinoma was investigated.

Patients and Methods: Totally, 59 specimens of liver were collected from two health care centers affiliated to Shahid Beheshti University of Medical Sciences, including 22 specimens of hepatocellular carcinoma, 18 specimens of cirrhosis and 19 normal specimens of liver. Polymerase chain reaction was used to determine the presence of H. pylori in liver samples using H. pylori gene-specific primers.

Results: 16srRNA of Helicobacter genus were found in 31.8% of hepatocellular carcinoma and 16.7% of cirrhotic specimens, however, we could not find this gene in normal samples. Meanwhile, the presence of ureC and cagA genes specific for H. pylori were investigated in positive specimens to confirm the H. pylori infection, however, these genes

were not detected.

Conclusion: Helicobacter infection exists in liver of patients with hepatocellular carcinoma. However, further studies are necessary to confirm this association.

Keywords

Hepatocellular carcinoma, Cirrhosis, Helicobacter pylori.

© 0, Archives of Clinical Infectious Diseases. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Full Text

Full text is available in PDF

COMMENTS

LEAVE A COMMENT HERE: