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Human Papillomavirus (HPV) Detection in Biopsies from Cervical Cancer Patients; A Population–Based Study from Iran

AUTHORS

Mohammad Niakan 1 , * , Fariba Yarandi 2 , Maryam Entezar 2

AUTHORS INFORMATION

1 Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, IR Iran

2 Department of Gynecology and Obstetrics, Tehran University of Medical Sciences, Tehran, IR Iran

How to Cite: Niakan M, Yarandi F, Entezar M. Human Papillomavirus (HPV) Detection in Biopsies from Cervical Cancer Patients; A Population–Based Study from Iran, Arch Clin Infect Dis. 2009 ; 4(1):e93397.

ARTICLE INFORMATION

Archives of Clinical Infectious Diseases: 4 (1); e93397
Published Online: January 30, 2009
Article Type: Brief Report
Received: May 12, 2019
Accepted: July 22, 2008

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Abstract

Background: Human papillomavirus (HPV) is associated with various benign and malignant lesions including genital condyloma and anogenital cancer. The presence of HPV-DNA was studied in archival biopsies of high- and intermediate-risk lesions for cervical carcinoma in women referred to Mirza hospital in Tehran.

Patients and methods: Totally, 105 Iranian archived biopsies collected during February and November 2006. HPVDNA was isolated from the biopsies and detected by means of consensus polymerase chain reaction (PCR) detecting a broad spectrum of genital HPV types.

Results: Totally, 26 samples (24.7%) were positive for oncogenic HPV-DNA. Risk of HPV infection was significantly higher in biopsies obtained from patients with confirmed squamous cell carcinoma (SCC) who started sexual activity more recently (≤4 years ago) when compared with those who started earlier (≥10 years ago). HPV-16 was more frequently detected in biopsies of younger women.

Conclusion: HPV was more frequently detected in young women. Our data confirm the usefulness of this method for detection of HPV in archival biopsies.

Keywords

Human papillomavirus (HPV) Cervical cancer Archival biopsy samples Polymerase chain reaction (PCR)

© 2009, Archives of Clinical Infectious Diseases. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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